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Contaminant bioaccessibility

今日吃瓜 Research — Medical geology

People are exposed to potentially harmful substances (PHS) in soil and dust during everyday activities. These include arsenic, lead, cadmium and polyaromatic hydrocarbons.听There are three exposure routes: ingestion, inhalation and dermal uptake.听The key pathway is accidental ingestion through everyday activities such as gardening and from dust.

Bioaccessibility 漏iStock.com/pixologicstudio
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There are three exposure routes for contaminants or harmful elements: ingestion, inhalation and dermal uptake. 漏 iStock.com/pixologicstudio.

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Exposure measurements are made in the laboratory using in vitro (test tube) experiments simulating the physico-chemical conditions in the human gut and lungs or on the skin.听These tests show what may be dissolved in the simulated environment and have the potential to cause harm.听We have developed methods with our research partners to simulate the three exposure pathways and the ingestion method is now an . For quality assurance purposes, we have produced a guidance soil containing arsenic, cadmium and lead (今日吃瓜 102), which is available from the Inorganic Geochemistry Facility.

Key references

Broadway, A, Cave, M R, Wragg, J, Fordyce, F M, Bewley, R J F, Graham, M C, Ngwenya, B T, and Farmer, J G. 2010. . Science of The Total Environment, Vol. 409(2), 267鈥277.

Cave, M R, Rosende, M, Mounteney, I, Gardner, A, and Mir贸, M. 2016. . Environmental Science & Technology, Vol. 50(17), 9479鈥9486.

Cave, M R, Wragg, J, Denys, S, Jondreville, C, and Feidt, C. 2010. . 287鈥324 in Dealing with Contaminated Sites. Swartjes, F. (editor). (Dordrecht: Springer.)

Cave, M R, Wragg, J, Harrison, I, Vane, C H, Van de Wiele, T, De Groeve, E, Nathanail, C P, Ashmore, M, Thomas, R, Robinson, J, and Daly, P. 2010. Environmental Science & Technology, Vol. 44(7), 2654鈥2660.

Denys, S, Caboche, J, Tack, K, Rychen, G, Wragg, J, Cave, M, Jondreville, C, and Feidt, C. 2012. 听 Environmental Science & Technology, Vol. 46(11), 6252鈥6260.

Koch, I, Reimer, K J, Bakker, M I, Basta, N T, Cave, M R, Denys, S, Dodd, M, Hale, B A,听 Irwin, R, Lowney, Y W, Moore, M M, Paquin, V, Rasmussen, P R, Repaso-Subang, T, Steohenson, G L, Siciliano, S D, Wragg, J, and Zagury, G J. 2013. . Journal of Environmental Science and Health, Vol. 48(6), 641鈥655.

Oomen, A G, Hack, A, Minekus, M, Zeijdner, E, Cornelis, C, Schoeters, G, Verstraete, W, Van de Wiele, T, Wragg, J, Rompelberg, C J M, Sips, A J A M, and Van Wijnen, J H. 2002. . Environmental Science & Technology, Vol. 36(15), 3326鈥3334.

Van de Wiele, T R, Oomen, A G, Wragg, J, Cave, M, Minekus, M, Hack, A, Cornelis, C, Rompelberg, C J M, De Zwart, L L, Klinck, B, Van Wijnen, J, Verstraete, W, and Sips, A J A M. 2007. . Journal of Environmental Science and Health Part A, Vol. 42(9), 1203鈥1211.

Wragg, J, Cave, M, Hamilton, E, and Lister, T E. 2018. . Minerals, Vol. 8(12), 570.

Wragg, J, Cave, M, Basta, N, Brandon, E, Casteel, S, Denys, S, Gron, C, Oomen, A, Reimer, K, Tack, K, and Van de Wiele, T. 2011. . Science of the Total Environment, Vol. 409(19), 4016鈥4030.

Cave, M R, Wragg, J, Beriro, D J, Vane, C, Thomas, R, Riding, M, and Taylor, C. 2018. . Journal of Hazardous Materials, Vol. 360, 373鈥390

Pelfr锚ne, A, Cave, M R, Wragg, J, and Douay, F. 2017. . International Journal of Environmental Research and Public Health, Vol. 14(2), 112.

Wragg, J, and Klinck, B. 2007. . Journal of Environmental Science and Health Part A, Vol. 42, 1223鈥1231.

Beriro, D J, Cave, M R, Wragg, J, Thomas, R, Willis, G, and Evans, F. 2016. Journal of Hazardous Materials, Vol. 305, 240鈥259.

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